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USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVUSE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS PRODUCTS
USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVUSE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS PRODUCTS
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机译:噻唑化合物用于预防和逆转噻唑化合物用于预防和逆转高级糖基化终产物形成的高级糖基化的形成
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摘要
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
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