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HEXITOL CONTAINING OLIGONUCLEOTIDES AND THEIR USE IN ANTISENSE STRATEGIES
HEXITOL CONTAINING OLIGONUCLEOTIDES AND THEIR USE IN ANTISENSE STRATEGIES
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机译:含己糖的寡核苷酸及其在反战略中的应用
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摘要
The present invention relates to novel oligomers comprising 1,5-anhydro-2,3-dideoxyhexitol nucleotide analogues and deoxyribose nucleotides. The invention further relates to complex consisting ofthe novel oligomer and a complementary single-stranded or double-stranded oligonucleotide. Pharmaceutical compositions, comprising the oligomer and/or the complex and the use of both in molecular biology and genetic engineering like hybridization, isolation of nucleic acids, site specific DNA modification and mapping.
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