Ethylamido fluorene derivatives and pharmaceutical compositions containing them

摘要

OneThe compound and manufacture of the technical field to which the invention belongs are recorded within the scope of the request.TwoThe invention is intended to solve the technical problem of the development of a new regular compound with the properties of melatcmergic, which is useful for the treatment of sleep disorders.ThreeThe gist of the solution of the technical subject (I) compounds or their pharmaceutically permitted solvent compounds: EM file = "utm00001. TIF" he = "36" id = "1" wi = "140" gtX is hydrogen.Halogen.0H or 0ZZ is C sb 1 6 sb gt-(CH sb 2 / sb) m-CF sb 3 / sb (m is 0 to 2): CD sb 3 / sb or- (CH sb 2 m 'emi file = "utm00002.tif" he = "11" id = "2" wi = "20" / raw (m' is 1 to 3): n is 1 or 2 R is C sb 1 / sb sb-/ sb sb 6 / sb alkyl,C 26lt sb 26gt 3 26lt 2Fsb 26gt 26lt sb 26gt 26lt 2Fsb 26gt 26lt sb 26gt 6 26lt 2Fsb 26gtC 26lt sb 26gt 2 26lt 2Fsb 26gt 26lt sb 26gt 26lt 2Fsb 26gt 26lt sb 26gt 4 26lt 2Fsb 26gtC 26lt sb 26gt 1 26lt 2Fsb 26gt 26lt sb 26gt 6 26lt 2Fsb 26gtOr C sb 1 / sb sb-/ sb sb 6 / sb alkoxy substituted C sb 1 / sb sb-/ sb sb 6 / sb alkyl.FourThe invention is an important biological time difference disorder and sleep disorder treatment agent.