A fusion protein of the surface antigen protein of the hepatitis B virus and the antigenic determinant site of the herpes simplex virus glycoprotein

摘要

The present invention relates to a fusion protein of a surface antigen protein of the hepatitis B virus (HBV) and an antigenic determinant site protein of gD of the surface antigen of Herpes Simplex Virus-2 (HSV) A fusion gene encoding a fusion protein in which a gD antigenic determinant site protein of HSV-2 surface antigen protein is fused with a surface antigen protein of HBV, and a bistronic expression vector in which the selectable gene is regulated by one promoter The fusion protein of the gD antigenic determinant site protein prepared by culturing the transformed CHO cell line and the surface antigen protein of HBV can be used as a combined vaccine having high immunity against HBV-2 and HBV.