FIELD:biochemistry,aminoacids,peptides.SUBSTANCE:product:Nα-2-(4-nitrophenylsulfonyl)-ethoxycarbonyl-amino acids: 4-NO2-C6H4-S(O)2-CH2-CH2-O-C(O)-NR1-CHR2-COOH where: R1 - hydrogen; R2 - hydrogen, methyl, isopropyl, methylpropyl, tert.-butoxymethyl, 1-tert.-butoxyethyl, 2-methylthioethyl, benzyl, carboxamidoalkyl, tert.-butoxycarbonylalkyl, or they form together propylene radical. Yield is up to 86%. Reagent 1: the corresponding amino acid. Reagent 2: 2-(4-nitrophenylsulfonyl)-ethylchloroformate. Reaction conditions: aqueous-organic solvent, in the presence of base, at 0-40 C. Synthesized compounds were used as Nα-protected amino acids for solid phase synthesis of peptides. EFFECT: improved method of synthesis, increased yield. 2 tbl
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