Solid-phase synthesis utilizing azido-alpha-amino acids:reduction of azido-protected proline

摘要

During an evaluation of azido-alpha-amino acids and their utility in solid-phase peptide chemistry,the octapeptide angiotensin II and a tripeptide thyrotropin-releasing hormone (TRH) analog have been prepared using Meldal's procedure.A necessary novel step was the reduction of the azido moiety of L-proline,a secondary amine constrained by a ring,to the corresponding free amine for coupling and peptide elongation.