Protected amino acid derivatives of the general formula ##STR1## wherein R.sub.1 represents hydrogen atom, and R.sub.2 represents hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, tert- butoxymethyl, 1- tert-butoxyethyl, 2-methylthioethyl, benzyl, carboxamidomethyl, 2- carboxamidoethyl, tert-butoxycarbonylmethyl, 2- (tert-butoxycarbonyl)ethyl, 4-(tert-butoxycarbamido)butyl, 4-tert- butoxybenzyl, indolyl-3-methyl, S- (triphenylmethyl)thiomethyl, 1- (triphenylmethyl)imidazolyl-4-methyl, 3-(N. sup.G -mesitylenesulfonyl) guanidinopropyl, N-xanthylcarboxamidomethyl, 2- (N-xanthylcarboxamido) ethyl or S-(acetamidomethyl)thiomethyl; or R.sub.1 and R.sub.2 together represent propylene radical. Methods for the preparation of said derivatives are provided, and a process for solid phase peptide synthesis using said derivatives is described.
展开▼
机译：通式## STR1 ##的受保护的氨基酸衍生物，其中R 1代表氢原子，R 2代表氢，甲基，异丙基，1-甲基丙基，2-甲基丙基，叔丁氧基甲基，1-叔丁氧基乙基，2-甲基硫乙基，苄基，羧酰胺甲基，2-羧酰胺基乙基，叔丁氧基羰基甲基，2-（叔丁氧基羰基）乙基，4-（叔丁氧基氨基甲酰基）丁基，4-叔丁氧基苄基，吲哚基-3-甲基， S-（三苯基甲基）硫代甲基，1-（三苯基甲基）咪唑基-4-甲基，3-（N.g.G-亚甲基磺酰基）胍基丙基，N-黄基羧酰胺基甲基，2-（N-黄基羧酰胺基）乙基或S-（乙酰胺基甲基）硫代甲基; R 1和R 2一起表示亚丙基。提供了用于制备所述衍生物的方法，并且描述了使用所述衍生物进行固相肽合成的方法。
展开▼
