7-ACYL-3-SUBSTITUTED CARBAMOYLHYDROXYCEPHEMS, METHODS OF THEIR SYNTHESIS, SUBSTITUTED CARBAMOYLHYDROXY-3-CEPHEMS, METHODS OF THEIR SYNTHESIS AND ANTIBACTERIAL COMPOSITION

摘要

A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1): CHEM wherein A means a -CH= or -N= group; R1 denotes a hydroxyl, lower alkoxyl, fluorine-substituted lower alkoxyl or protected hydroxyl group; R2 and R3 are the same or different and individually represent a lower alkyl, hydroxyl-substituted lower alkyl, a carbamoyl-substituted lower alkyl group or cyano-substituted lower alkyl group, R2 is a hydrogen atom and R3 is a lower alkoxyl or alkyl group optionally substituted by one or more halogen atoms, or the group CHEM means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said heterocyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R4 denotes a carboxyl or protected carboxyl group; or a pharmaceutically acceptable salt thereof; and a process for the preparation thereof; use thereof as well as an antibacterial composition containing the above cephem compound.