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1,4,5-TRIPHENYL-PYRAZONE CONDITIONS FOR THE TREATMENT OF IMPORTS AND IMPORTS CONCERNED
1,4,5-TRIPHENYL-PYRAZONE CONDITIONS FOR THE TREATMENT OF IMPORTS AND IMPORTS CONCERNED
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机译:1,4,5-三苯并吡喃酮条件的进口和处理
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摘要
A class of 1,4,5-triphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I IMAGE I wherein R1 is one or more groups independently selected from hydrido, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl, methylsulfonyl, hydroxy, nitro, amino, N-methylamino, acetamido, trifluoromethyl, bromo, iodo, fluoro and chloro; wherein R2 is selected from hydrido, methyl, ethyl, cyano, trifluoromethyl, difluorochloromethyl, difluoromethyl, pentafluoroethyl and heptafluoropropyl; wherein R3 is one or more groups independently selected from hydrido, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl, methylsulfonyl, hydroxy, nitro, amino, N-methylamino, acetamido, trifluoromethyl, bromo, iodo, fluoro and chloro; and wherein R4 is methyl; or a pharmaceutically-acceptable salt thereof.
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