NUCLEIC ACID FRAGMENTS DERIVED FROM THE HIV-1 VIRUS GENOME, CORRESPONDING PEPTIDES AND THEIR APPLICATIONS AS REAGENTS FOR EVALUATING THE RISK OF MATERNO-FETAL TRANSMISSION OF HIV-1

摘要

Nucleic acid fragments derived from the genome of the human immunodeficiency virus type 1 (HIV-1) as well as corresponding peptides and their applications as reagents for screening and assessing the risk of maternal-fetal transmission of HIV- 1. BR/ Said nucleic acid fragments, derived from the gene coding for a fragment of the matrix protein p17 of HIV-1, essentially consist of 21 to 90 nucleotides and include at least the sequence represented by the formula: Y5 Y6 Y7 Y8 Y9 Y10 Y11, in which: Y5 represents AAA, AAG, GAA, Y6 represents ATA, TTA, CTG, GTA, CTA, GTG, ATG, Y7 represents GAG, GAA, Y8 represents GAA, AAG, Y9 represents ATA , GTA, CTA, GAA, GAG, GAC, GAT, AGA, Y10 represents CAA, CAG, CGA, Y11 represents AAA, AGT, AAG, AAT, CAT, AAC, ACC. BR/ Said peptides, consisting of 7 to 30 amino acids and including at least the amino acid sequence 103 to 109 of the viral matrix protein p17 of HIV-1, are represented és by the formula X2 X3 Glu X4 X5 X6 X7, in which: X2 represents Lys, Glu, X3 represents IIe, Leu, Val, Met, X4 represents Glu, Lys, X5 represents IIe, Val, Glu, Arg, Leu, X6 represents GIn, Arg and X7 represents Lys, Ser, Asn, His, Thr.