Derivatives of 3 - (omega - (4 - (thieno (3,2 - c) of the compounds - 4 - yl) piperazin - 1 - yl) alkyl) - 3,4 - dihydroquinolin - 2 (1h) - one, their preparation and their application of international application no.

摘要

Thieno-pyridinyl piperazinyl dihydro quinolinones of formula (I) and their salts, in racemic or enantiomeric form, are new. R1, R2 = H, halogen, NH2, OH, NO2, CN, 1-6C alkyl or alkoxy, CF3, OCF3, COOH, COOR4, CONH2, CONHR4, CONR4R5, SR4, SO2R4, OSO2CF3, NHCOR4, NHSO2R4, or N(R4)2; R3 = H, 1-4C alkyl , (CH2)pOH, (CH2)pNH2, (CH2)nCOOH, (CH2)nCOOR4, (CH2)nCONH2, (CH2)nCONHOH, (CH2)pSH, (CH2)nSO3H, (CH2)nSO2NH2, (CH2)nSO2NHR4, (CH2)nSO2NR4R5, (CH2)nCONHR4, (CH2)nCONR4R5, (CH2)pNHCOR4, -(CH2)pNHSO2R4, or (CH2)pOCOR4; R4, R5 = 1-4C alkyl; n = 1-4; and p, m = 2-4.