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DERIVATIVES OF 4- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) QUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DERIVATIVES OF 4- (OMEGA- (4- (THIENO (3,2-C) PYRIDIN-4-YL) PIPERAZIN- 1-YL) ALKYL) QUINOLEIN-2 (1H) -ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
Quinoline-2(1H)one derivatives of formula (I) and their salts with acids and bases are new. In (I), A = 4-(thieno3,2-cpyridin-4-yl)piperazin-1-yl, or 4-(4-fluorobenzoyl)piperidin-1-yl; R1, R2 = e.g. H, halo, amino, OH, NO2, CN, 1-6C alkyl or alkoxy, CF3, CF3O, COOH, COOR4 etc.; R4, R5 = 1-4C alkyl; R3 = e.g. H, 1-4C alkyl, -(CH2)pOH, -(CH2)pNH2, -(CH2)nCOOH, -(CH2)pNHSO2R4; n = 1-4; p = 2-4; and m = 2-4.
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机译：式（I）的喹啉-2（1H）one衍生物及其与酸和碱的盐是新的。在（I）中，A ＝ 4-（噻吩3,2-吡啶基-4-基）哌嗪-1-基或4-（4-氟苯甲酰基）哌啶-1-基; R1，R2 =例如H，卤素，氨基，OH，NO2，CN，1-6C烷基或烷氧基，CF3，CF3O，COOH，COOR4等; R4，R5 ＝ 1-4C烷基; R3 =例如H，1-4C烷基，-（CH2）pOH，-（CH2）pNH2，-（CH2）nCOOH，-（CH2）pNHSO2R4; n = 1-4; p = 2-4;并且m = 2-4。
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