Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors

摘要

A compound of the formula: ##STR1## wherein: each of R.sub.1, R.sub.1 ', R.sub.2 and R.sub.2 ' independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group, R.sub.3 is OH, OCH.sub.3, CH.sub.2 COOH or ##STR2## wherein each of R.sub.2" and R.sub.2 '41 independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group and:PPA=NH.sub.2, X=P(OH), Y=Z=C, B=OCH. sub.3, orPPA=OH, X=P(OH), X=Z=C, B (if present)=OCH.sub.3, or PPA=OCO(CH.sub.2).sub.n NH.sub.2, X=P(OH), Y=Z=C, B=OCH.sub.3, PPwherein n=1-10, orPPA=OH, X=P(OH), Y=Z=C, B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, or P PA=OH, X=P(OH), Y=Z=C, B=(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orPPA=NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub. 3, orP PA=OH, X=Z=C, Y=P(OH), B (if present)=OCH.sub.3, orP PA=OCO(CH.sub.2).sub.n NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub.3, wherein n=1-10, orPPA=OH, X=Z=C, Y=P(OH), B=O(CH.sub.2).sub.n CO. sub.2 H, wherein n=1-10, orPPA=OH, X=Z=C, Y=P(OH), B=(CH. sub.2).sub.n CO.sub.2 H, wherein n=1-11, or PPA=NH.sub.2, X=Y=C, Z=P(OH), B=OCH.sub.3, orP PA=OH, X=Y=C, Z=P(OH), B (if present)=OCH.sub.3, orPP A=OCO(CH.sub.2).sub.n NH.sub. 2, X=Y=C, Z=P(OH), B=OCH.sub.3, wherein n=1- 10, orPPA=OH, X=Y=C, Z=P(OH), B=O(CH.sub.2).sub.n CO.sub. 2 H, wherein n=1-10, or PPA=OH, X=Y=C, Z=P (OH), B=(CH. sub.2).sub.n CO.sub.2 H and n=1-11 is disclosed. The compounds may be use to inhibit binding of Lipid A to Lipid A receptors.