Long term storage of red cells in unfrozen solution

摘要

A method for prolonging storage shelf-life of red blood cells under refrigerated conditions includes separating plasma from the red blood cells while retaining residual plasma and adding a biologically compatible solution having an effective osmolality of less than 70 mOsm to the red blood cells. The biologically compatible solution preferably includes at least one penetrating solute that penetrates red cells more slowly than water and substantially no non-penetrating anions and non- penetrating non-electrolytes.