Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856

摘要

N-alkanoyl derivatives of staurospodne represented by the formula I ##STR1## wherein R.sub.a and R.sub.b are each H or ##STR2## wherein R.sub. 1 and R.sub.2 are independently H or --OH or --OCH.sub.3 and R.sub.3 is OH, NHCH.sub.3, NCH COCH.sub.3 or NHCOCH.sub.3 and R.sub.4 is OH or H and, stereochemical isomers thereof with the provisos that (1) when R.sub.a and R.sub.b ═A, and R.sub.1═H.sub.2 or OH R.sub.3 is not NHCH.sub. 3 ; (2) when R.sub.a and R.sub.b═ B, then R.sub.1 ═R.sub.4 ═ OH or R.sub.1 ═R.sub.4 ═H; (3) when R.sub. a ═R.sub.b ═H R. sub.1 ═--OCH.sub.3, and (4) when R.sub.a and R.sub.b ═A, and R. sub.1 ═H and R.sub.2 ═OCH.sub.3, then R3 is not and ##STR3## pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti- inflammatory effect in warm-blood animals such as man are disclosed.