Inhibitor and resistance formation inhibitor of narcotic analgesic

摘要

The following formula: r2-ch2conh-r1 (in Formula 1, R1 indicates pyridyl group, substituted pyridyl group, phenyl group, or substituted phenyl group; R2 represents a 2-oxo-1-pyrrolidinyl group having a substituent) as an active ingredient, and narcotic analgesic A drug that suppresses the formation of dependency and / or suppresses the formation of resistance to analgesic action by narcotic analgesics.