5-AMINOALKYL-4-AMINOMETHYL-3-HYDROXYPYRIDINE DERIVATIVE AND MAILLARD REACTION INHIBITOR CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To obtain the subject new compound having a Maillard reactioninhibiting activity and useful as a medicine for treating diseases related to Maillard reaction, etc., and as an additive for foods, etc. ;SOLUTION: A compound of formula I (A is a lower alkylene; R¹, R², R³ are each H, a lower alkyl; R⁴ is an aryl, a hydroxyaryl, etc.; R⁵ is H, a lower alkyl), e.g. N-phthaloylpyridoxamine. The compound of formula I is produced by reacting a halide of formula II (R⁶ is an amino having a protecting group; R⁷ is an OH-protecting group) with an amine compound of formula III and subsequently removing the protecting group from the reaction product.;COPYRIGHT: (C)1998,JPO