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USE OF RE-DISPERSIBLE POLYMERIC POWDER OR POLYMERIC GRANULE AS BINDER AND SOLID PHARMACEUTICAL DOSAGE FORM
USE OF RE-DISPERSIBLE POLYMERIC POWDER OR POLYMERIC GRANULE AS BINDER AND SOLID PHARMACEUTICAL DOSAGE FORM
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机译:使用可再分散的聚合物粉末或聚合物颗粒作为粘合剂和固体药物制剂形式
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摘要
PROBLEM TO BE SOLVED: To obtain a polymeric powder or polymeric granules comprising a water-insoluble polymer and a water-soluble polymer, suitable as a binder for production of solid pharmaceutical dosage forms and capable of rapidly releasing active substance(s). SOLUTION: This polymeric powder or granules as binder comprise(s) 10-95 wt.% of polyvinyl acetate, 5-90 wt.% of an N-vinylpyrrolidone-contg. polymer, 0-20 wt.% of another water-soluble or water-swellable substance and 0-20 wt.% of a water-insoluble pulverizing agent, and in some cases, other additive(s). The content of the binder in the other objective dosage form is 0.5-20 wt.%. This polymeric powder or granules has (have) remarkable binding action, and does not disintegrate the dose form and also does not virtually affect the release of the active substance(s) included in the preparation within the concentration range of 0.5-20 wt.%, based on the whole weight of the prescribed preparation as the dosage form.
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