Thiol compounds with Inhibitory activity of metalopeptidasa; Process for preparing Said Derivatives, Pharmaceutical compositions loscontienen

摘要

Invention refers to equation (I),Where R is a commodity group or R4 group that can be converted into an organic group; R1 is a right angle or branched C2-C4 clot, or a group of arilo or arilalquilo, which has 1-6 carbon atoms in the base part of arilo which is unfenilo, or a 5-6 member heteroaromatic cycle, composed of one or two heteroatoms selected from the nitrogen, oxygen and sulfur groups, Replace with one or more substitutes the same or different substitutes selected from the halogen atom, oxyhydrogen, oxypropylene, asphalt, asphalt, asphalt or carbonate group containing 1 to 6 carbon atoms,C1-C3 is 1-6 tomos in the coke oil part of matrix group, carboxi group, nitro group, aminobenzene or aminobenzene group, acid group, aminobenzene group, diphenyl monophosphate group, diphenyl-o-monophosphate group, or carbon dioxide carbon dioxide thyroid gland group with fluorinated atom adjacent to or larger than atom; R2 is hydrogen atom, Rectal synthesis of C1-C4 tar or a bencilo group; R3 is a phenyl compound, which is replaced by 5 to 6 members of the heteroaromatic cycle, which contains one or two heteroatoms of nitrogen, oxygen and sulfur selected from rupo, while the phenyl and heteromorphic groups are replaced by one or more substitutes, 1. R1 is the same or different;R4 is a group of C1-C4 rectoceles or branches or a group of phenyl; remover procedure and drug synthesis with active ingredients. Formula compound (I) has the mixed biological activity of ACE ynep and can be used in the treatment of cardiovascular diseases.