THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH THIOL DERIVATIVES AND PROCESS FOR THEIR USE

摘要

Thiol derivatives of formula RCH2CHR1CONHCH(CH2R3)COOR2 (I) and their salts are new: R = mercapto or R4COS convertible in an organism to a mercapto group; R1 = 2-4C alkyl, Ar or Ar(1-6C)alkyl; Ar = phenyl or Het (both optionally substituted by one or more halo, OH, TO, T, TS, TSO2, TOCO, 1-3C alkyl (containing one or more F atoms), carboxy, nitro, NH2, NH2CO, acylamino, NH2SO2, TNH, (T)2N, TNHCO or (T)2NCO); Het = a 5-6 membered aromatic heterocycle containing 1-2 N, O or S atoms; R2 = H, 1-4C alkyl or benzyl; R3 = phenyl substituted by Het (optionally substituted as for Ar); R4 = 1-4C alkyl or phenyl; T = 1-6C alkyl.