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PROCESS FOR THE PREPARATION OF SOLID PHARMACEUTICAL DISPERSIONS AND SOLID PHARMACEUTICAL DISPERSIONS WITH IMPROVED SOLUBILITY CHARACTERISTICS
PROCESS FOR THE PREPARATION OF SOLID PHARMACEUTICAL DISPERSIONS AND SOLID PHARMACEUTICAL DISPERSIONS WITH IMPROVED SOLUBILITY CHARACTERISTICS
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机译:具有改善的溶解度特征的固体药物分散体和固体药物分散体的制备方法
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摘要
A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.
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