CHEMOTACTIC FACTORS FOR HUMAN SPERMATOZOA AND THEIR USE IN THE PREPARATION OF MEDICAMENTS FOR HUMAN ASSISTED FERTILIZATION

摘要

The invention relates to chemotactic factors for human spermatozoa that are purifiable from human follicular fluid. The factors are of peptidic and hydrophilic nature. The first factor has a molecular size of about 13 kDa and, the other, an apparent molecular size smaller that 1.3 kDa, as determined by high pressure gel filtration, as shown in the figure. They are for use in procedures related to human fertilization, particularly artificial insemination, in vitro fertilization, micromanipulation and direct microinjection of sperm to oocytes.