PROCESS FOR THE PURIFICATION OF CLAVULANIC ACID OR A DERIVATIVE THEREOF FROM A FERMENTATION BROTH BY USING MICROFILTRATION

摘要

PCT No. PCT/GB96/02083 Sec. 371 Date Jun. 1, 1998 Sec. 102(e) Date Jun. 1, 1998 PCT Filed Aug. 27, 1996 PCT Pub. No. WO97/08175 PCT Pub. Date Mar. 6, 1997Provided is a process for preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof including removing solids from a clavulanic acid containing fermentation broth by microfiltration to form a first filtrate, further removing solids from the first filtrate by ultrafiltration to form a second filtrate, concentrating the second filtrate by removal of water, and treating the concentrated second filtrate to isolate clavulanic acid or a pharmaceutically acceptable salt or ester thereof, characterized in that the first filtrate is filtered using an ultrafiltration membrane having a molecular weight cut-off of 10 to 30 kD and a permeate flow rate of 10 to 30 lm-2 h-1.