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PROCESS FOR THE PREPARATION OF STABLE CONCENTRATE OF FACTOR VIII - VON WILLEBRAND FACTOR COMPLEX HAVING HIGH SPECIFIC ACTIVITY
PROCESS FOR THE PREPARATION OF STABLE CONCENTRATE OF FACTOR VIII - VON WILLEBRAND FACTOR COMPLEX HAVING HIGH SPECIFIC ACTIVITY
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机译:具有高比活度的稳定浓缩因子VIII-VON WILLEBRAND因子复合物的制备工艺。
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摘要
The invention relates to a process for the preparation of a concentrate of factor VIII-von Willebrand factor complex having high specific activity from non-cryoprecipitated plasma. The process comprises a pre-purification commenced by coagulating with barium chloride and adsorption on aluminium hydroxide. The process then comprises purification by chromatography on an anion exchange resin of the DEAE-Fractogel type. The process comprises a step of viral inactivation by the solvent/detergent treatment. The process also enables fibrinogen, albumin, immunoglobulins, antithrombin III, fibronectin and prothrombin complex to be recovered from the same plasma. The various concentrates obtained by the process are suitable for the therapeutic use.
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