首页> 外国专利> PROCESS FOR THE PREPARATION OF STABLE CONCENTRATE OF FACTOR VIII - VON WILLEBRAND FACTOR COMPLEX HAVING HIGH SPECIFIC ACTIVITY

PROCESS FOR THE PREPARATION OF STABLE CONCENTRATE OF FACTOR VIII - VON WILLEBRAND FACTOR COMPLEX HAVING HIGH SPECIFIC ACTIVITY

机译:具有高比活度的稳定浓缩因子VIII-VON WILLEBRAND因子复合物的制备工艺。

摘要

The invention relates to a process for the preparation of a concentrate of factor VIII-von Willebrand factor complex having high specific activity from non-cryoprecipitated plasma. The process comprises a pre-purification commenced by coagulating with barium chloride and adsorption on aluminium hydroxide. The process then comprises purification by chromatography on an anion exchange resin of the DEAE-Fractogel type. The process comprises a step of viral inactivation by the solvent/detergent treatment. The process also enables fibrinogen, albumin, immunoglobulins, antithrombin III, fibronectin and prothrombin complex to be recovered from the same plasma. The various concentrates obtained by the process are suitable for the therapeutic use.
机译:本发明涉及从非冷沉淀血浆中制备具有高比活性的因子VIII-von Willebrand因子复合物浓缩物的方法。该方法包括通过用氯化钡凝结并吸附在氢氧化铝上而开始的预纯化。然后该方法包括在DEAE-Fractogel类型的阴离子交换树脂上通过色谱法纯化。该方法包括通过溶剂/洗涤剂处理使病毒灭活的步骤。该方法还可以从同一血浆中回收纤维蛋白原,白蛋白,免疫球蛋白,抗凝血酶III,纤连蛋白和凝血酶原复合物。通过该方法获得的各种浓缩物适合用于治疗用途。

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