首页> 外国专利> NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES

NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES

机译:新型喜树碱类似物,其制备方法,用作药物的药物以及包含上述类似物的药物组合物

摘要

A camptothecin analogue characterised in that the hydroxy lactone of the camptohecin is a [err]-hydroxy lactone or the corresponding[err]-hydoxyacid, resulting from the opening of said lactone, or a derivative of said [err]-hydroxyacid, or a pharmaceutically acceptable saltthereof, is disclosed. In particular, compounds of formulae (I) and (II) are disclosed. Methods for preparing the compounds of fomulae (I).and (II), pharmaceutical compositions containing said compounds, and their use, particularly as topoisomerase inhibitors and antitumoraldrugs, are also disclosed.
机译:一种喜树碱类似物,其特征在于喜树碱的羟基内酯是[err]-羟基内酯或相应的由所述内酯或所述[err]-羟酸的衍生物或药学上可接受的盐打开而产生的[err]-羟酸其公开。特别地,公开了式(I)和(II)的化合物。制备式(I)的化合物的方法。(II),含有所述化合物的药物组合物及其用途,特别是作为拓扑异构酶抑制剂和抗肿瘤药药物,也被披露。

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