NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES

摘要

A camptothecin analogue characterised in that the hydroxy lactone of the camptohecin is a [err]-hydroxy lactone or the corresponding[err]-hydoxyacid, resulting from the opening of said lactone, or a derivative of said [err]-hydroxyacid, or a pharmaceutically acceptable saltthereof, is disclosed. In particular, compounds of formulae (I) and (II) are disclosed. Methods for preparing the compounds of fomulae (I).and (II), pharmaceutical compositions containing said compounds, and their use, particularly as topoisomerase inhibitors and antitumoraldrugs, are also disclosed.