首页> 外国专利> NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES

NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES

机译:新型喜树碱类似物,其制备方法,用作药物的药物以及包含上述类似物的药物成分

摘要

Camptothecin analogues where the camptothecin hydroxy lactone is: (i) a beta -hydroxy lactone; or (ii) the corresp. beta -hydroxy acid resulting from ring-opening of the aforementioned lactone; or a (iii) deriv. of the beta -hydroxy acid in (ii) or its one of its salts. Also claimed are new industrial prods. of formula (M) and (A). R1 = lower alkyl, lower alkenyl, lower alkynyl, halo(lower alkyl), lower alkoxy(lower alkyl) or lower alkylthio(lower alkyl); R20 = H or halo; R22 = F, Cl, or lower alkoxy; R23 = prim. hydroxy-protecting gp.; and R18, R19 = H, halo, lower alkyl, lower alkoxy or OH.
机译:喜树碱类似物,其中喜树碱羟基内酯是:(i)β-羟基内酯;或(ii)相应。由上述内酯开环得到的β-羟基酸;或(iii)派生。 (ii)中的β-羟基酸或其盐之一。还声称是新的工业产品。式(M)和(A)的基团。 R1 =低级烷基,低级烯基,低级炔基,卤代(低级烷基),低级烷氧基(低级烷基)或低级烷硫基(低级烷基); R 20 = H或卤素; R22 = F,Cl或低级烷氧基; R23 =灌注羟基保护剂R 18,R 19 = H,卤素,低级烷基,低级烷氧基或OH。

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