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DISPLAY AND USE OF FORMALINE-KILLED E. COLI BACTERIA THAT EXPECT THE COLONY FACTOR ANTIGUE (CFA) FOR VACCINATION AGAINST THE COLUMIN INFECTION / DIARRHOE IN PEOPLE
DISPLAY AND USE OF FORMALINE-KILLED E. COLI BACTERIA THAT EXPECT THE COLONY FACTOR ANTIGUE (CFA) FOR VACCINATION AGAINST THE COLUMIN INFECTION / DIARRHOE IN PEOPLE
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机译:显示和使用福尔马林杀灭的大肠杆菌细菌,该细菌有望对人的常见感染/腹泻疫苗进行免疫接种
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摘要
Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E. coli bacteria in humans. E. coli strains selected from different known strains each having the ability of expressing a certain type of colonization factor antigens are grown in a liquid culture medium. Finally formalin-killed E. coli strain having substantially preserved antigenic and hemagglutinating properties of said certain type of colonization factor antigens, is mixed with a pharmaceutically acceptable excipient and/or diluent. Further disclosed is a method of preventing an enteric infection caused by enterotoxigenic E. coli bacteria in humans, whereby a vaccine composition comprising inactivated E. coli strain is administered to a human being for the prevention of said infection.
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