首页> 外文OA文献 >Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant

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Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant

机译：口服ETEC疫苗的开发和临床前安全性和免疫原性评估，其中含有过量表达定殖因子CFA / I，CS3，CS5和CS6的灭活大肠杆菌和混合的LT / CT B亚基抗原，与单独的dmLT佐剂一起施用

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Holmgren J.; Bourgeois L.; Carlin N.; Clements J.; Gustafsson B.; Lundgren A.; Nygren E.; Tobias J.; Walker R.; Svennerholm A.-M.;
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年度 2013
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1. Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant [J] . Holmgren J., Bourgeois L., Carlin N., Vaccine . 2013,第20期

机译：口服ETEC疫苗的开发和临床前安全性和免疫原性评估，其中含有过量表达定殖因子CFA / I，CS3，CS5和CS6的灭活大肠杆菌和混合的LT / CT B亚基抗原，与单独的dmLT佐剂一起施用
2. Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein [J] . Lundgren A., Leach S., Tobias J., Vaccine . 2013,第8期

机译：评估含有CFA / I过表达细菌和重组产生的LTB / CTB杂合蛋白的口服灭活肠毒素性大肠杆菌原型疫苗的安全性和免疫原性的临床试验
3. Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6) [J] . Human vaccines & immunotherapeutics. . 2020,第2期

机译：肠毒素大肠杆菌（ETEC）双突变热不稳定毒素（DMLT）对由CFA / I / II / IV / IV MeFA型疫苗诱导的全系统免疫原性的辅助作用：剂量相关的抗体反应对七种ETEC胶粘物的增强（CFA / 我，CS1-CS6）
4. Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I CS1-CS6) [O] . Hyesuk Seo, Ti Lu, Sachin Mani, 2020

机译：产肠毒素的大肠杆菌（ETEC）双突变热不稳定毒素（dmLT）对CFA / I / II / IV MEFA ETEC疫苗诱导的全身免疫原性的辅助作用：剂量相关的对7种ETEC黏附素（CFA / ICS1-CS6）
5. Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study [O] . Lundgren Anna, Bourgeois Louis, Carlin Nils, 2014

机译：在双盲，随机，安慰剂对照的I期研究中，单独和与dmLT佐剂一起服用的改良口服灭活多价肠毒素大肠杆菌（ETEC）疫苗的安全性和免疫原性

Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant

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