PROCEDURES FOR THE PRODUCTION OF HUMAN CYTOMEGALOVIRUS (HCMV) GLYCOPROTEINS, CORRESPONDING ANTIBODIES AND HCMV VACCINES, AND RECOMBINANT VECTORS FOR THEM.

摘要

GLMOPROTEINS B AND H OF HCMV HAVE BEEN IDENTIFIED. THE GB PROTEIN IS CODED BY THE DNA IN THE HIND III FRAGMENT F OF THE HCMV GENOME LOCATED BETWEEN THE 1378 AND 4095 BASES OF THE F / D LEAGUE. PROTEIN GH IS CODED BY DNA IN FRAGMENT L OF HING III LOCATED BETWEEN BASES 228 AND 2456 OF LIGAND L / D. THE GENES HAVE BEEN INCORPORATED IN THE VECTORS OF THE RECOMBINANT VACCINE AND EXPRESSED IN THE HOSTING ANIMALS TO INCREASE THE NEUTRALIZING ANTIBODY OF THE HCMV, INDICATING THE POTENTIAL OF THE VACCINE. GLYCOPROTEINS MAY ALSO BE USED IN A WIDE VARIETY OF DIFFERENT WAYS, AS A VACCINE OR IN THE PRODUCTION, PURIFICATION OR DETECTION OF THE HCMV ANTIBODY.