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pharmaceutical compositions containing drugs NSAIDs and bile acids.

机译:包含药物NSAID和胆汁酸的药物组合物。

摘要

Anti-inflammatory drugs Nonsteroidal, such as indomethacin, AND OTHER COMPONENTS pharmaceutically active, are formulated with bile acids or other salts and conjugates. Bile acids PREVIOUSLY PROPOSED FOR APPLYING IN SUCH A BURDEN PLACED formulas have LIVER TOXIC UNACCEPTABLE and / or cells of the gastrointestinal tract, causing abnormal liver FUNCTION OR EROSION OF THE CELL. In this invention, BILIAR ACID IS A LOW DETERGENT bile acid, AS ursodeoxycholate. Stabilizing the bile acid FLUID RESULTS IN RECYCLING AND PREDICTABLE Enteropathy NSAIDs increased, S (and other drugs) AND REDUCED RISK OF TOXICITY.
机译:抗炎药非甾体药物,如消炎痛和其他具有药物活性的成分,可与胆汁酸或其他盐类和结合物一起配制。先前建议以这样的胆汁酸配方使用的胆汁酸具有不可吸收的肝毒性和/或胃肠道细胞,从而引起异常的肝功能或细胞侵蚀。在本发明中,胆汁酸是一种低洗涤剂胆汁酸,作为熊去氧胆酸。稳定胆汁酸循环和可预测肠病中的流体结果NSAIDs增加,S(和其他药物)增加并降低了毒性风险。

著录项

  • 公开/公告号ES2107038T3

    专利类型

  • 公开/公告日1997-11-16

    原文格式PDF

  • 申请/专利权人 CORTECS LIMITED;

    申请/专利号ES19930913350T

  • 发明设计人 BARNWELL STEPHEN GEORGE;

    申请日1993-06-11

  • 分类号A61K9/48;A61K9/14;A61K9/16;A61K9/50;A61K47/28;

  • 国家 ES

  • 入库时间 2022-08-22 02:54:40

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