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Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins bile acids and pharmaceutical drugs

机译:研究肠溶性肠凝胶对多种细菌毒素胆汁酸和药物的吸附能力

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摘要

Oral intestinal adsorbents (enterosorbents) are orally administered materials which pass through the gut where they bind (adsorb) various substances. The enterosorbent Enterosgel (Polymethylsiloxane polyhdrate) is recommended as a symptomatic treatment for acute diarrhoea and chronic diarrhoea associated with irritable bowel syndrome (IBS). Since 1980’s there have been many Enterosgel clinical trials, however, the detailed mechanism of Enterosgel action towards specific toxins and interaction with concomitantly administered medications has not been fully investigated. Our in vitro study assessed the adsorption capacity of Enterosgel for bacterial enterotoxins and endotoxin, bile acids and interaction with the pharmaceutical drugs; Cetirizine and Amitriptyline hydrochloride. Our data demonstrate the good adsorption capacity of Enterosgel for bacterial toxins associated with gastrointestinal infection, with a lower than the comparator charcoal Charcodote capacity for bile acids whose levels can be raised in IBS patients. Adsorption capacity for the two drugs varied but was significantly lower than Charcodote. These findings suggest that the mechanism of Enterosgel action in the treatment of gastrointestinal infection or IBS is adsorption of target molecules followed by removal from the body. This therapy offers a drug free approach to prevention and treatment of infectious and chronic non-infectious diseases, where intestinal flora and endotoxemia play a role.
机译:口服肠道吸收剂(口服吸收剂)是口服给药的材料,它们会穿过肠道,在那里它们结合(吸收)各种物质。肠吸收剂Enterosgel(聚甲基硅氧烷多酸盐)推荐作为对肠易激综合症(IBS)引起的急性腹泻和慢性腹泻的对症治疗。自1980年代以来,进行了许多Enterosgel临床试验,但是,尚未完全研究Enterosgel对特定毒素的作用以及与伴随给药的相互作用的详细机制。我们的体外研究评估了Enterosgel对细菌肠毒素和内毒素,胆汁酸的吸附能力以及与药物的相互作用。西替利嗪和阿米替林盐酸盐。我们的数据表明肠凝胶对与胃肠道感染相关的细菌毒素具有良好的吸附能力,但比IBC患者胆汁酸中可升高的胆汁酸活性炭的比较能力低。两种药物的吸附能力各不相同,但明显低于Charcodote。这些发现表明,肠胃凝胶在胃肠道感染或IBS治疗中的作用机制是吸附靶分子,然后从体内清除。这种疗法为预防和治疗肠道菌群和内毒素血症发挥作用的传染性和慢性非传染性疾病提供了一种无药物的方法。

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