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Use of herpes simplex virus orf p protein in repression of viral protein synthesis and related methods
Use of herpes simplex virus orf p protein in repression of viral protein synthesis and related methods
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机译:单纯疱疹病毒orf p蛋白在抑制病毒蛋白合成中的应用及相关方法
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摘要
The present invention is directed to methods and compositions relating to the treatment of herpes simplex virus infections and the screening of compounds for activity that inhibit or promote viral latency. The previously identified ORF P gene product now has been shown to interact with certain eukaryotic splicing factors and, in a cell infected with a herpesvirus containing a derepressed ORF P gene, ORF P can limit the splicing of at least two viral products. Given this function, it now is possible to screen for inhibitors and inducers of ORF P and, further, provide methods for maintaining and preventing viral latency.
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