Method of treating a mammal having a disease characterised by an overproduction or an upregulated production of TNF-alpha using biologically active compounds as inhibitors of TNF-alpha secretion

摘要

Compounds and methods are disclosed that are useful in inhibiting the TNF- alpha converting enzyme (TACE) responsible for cleavage of TNF- alpha precursor to provide biologically active TNF- alpha . The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as hydroxamates, thiols, phosphoryls and carboxyls.