A method for diagnosis and treatment of inflammatory bowel diseases including crohn's disease and chronic ulcerative colitis

摘要

The human Asthma Associated Factor 1 (AAF1) has been shown to up regulate the Th2 mediated immune response to antigen and to induce a Th2 mediated response in an animal which normally has a Th1 mediated response. Inflammatory bowel diseases (IBD) are dominated by a Th1 mediated, antigen induced, inflammatory response. Therefore, the invention involves the treatment of IBD by the up regulation of the Th2 mediated immune response induced by AAF1 or fragments thereof or other AAF1 agonists.