Heparan sulfate/heparin interacting protein compositions and methods of use

摘要

Disclosed are novel polynucleotides encoding mammalian heparan sulfate/heparin interacting proteins and methods for their use in a variety of diagnostic and therapeutic regiments, including recombinant production of the encoded heparin/heparan sulfate interacting proteins, peptide epitopes, synthetic derivatives, and mutagenized forms thereof. Also disclosed and claimed are methods and kits for their use in the modulation of blood coagulation, and the interaction with antithrombin-3. Methods and compositions for enrichment of particular heparin species are also disclosed.