INHIBITION OF PRIMARY AND/OR SECONDARY IMMUNE RESPONSE TO REPEAT ADENOVIRAL VECTOR ADMINISTRATION USING CD40L SPECIFIC ANTIBODIES

摘要

A method is provided for decreasing or eliminating an immune response to the administration of an adenoviral vector containing a transgene to an individual comprising co-administering to said individual an amount of an antibody specific for CD40L on CD4+ T lymphocytes such that primary and/or secondary immune responses to the adenoviral vector are diminished or eliminated and expression of the transgene persists.