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METHOD AND COMPOUNDS FOR CONTROLLING CAPACITATIVE CALCIUM ION ENTRY INTO MAMMALIAN CELLS
METHOD AND COMPOUNDS FOR CONTROLLING CAPACITATIVE CALCIUM ION ENTRY INTO MAMMALIAN CELLS
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机译:控制电容性钙离子进入哺乳动物细胞的方法和化合物
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摘要
A method for controlling capacitative calcium ion entry into a mammalian cell. The method is based on the discovery that mammalian transient receptor potential (trp) protein are essential for calcium ion entry. Two human trp proteins are disclosed. Htrp1 and Htrp3. The method involves treating cells with a trp-control agent to either raise or lower the amount of biologically active trp protein associated with the cell to thereby control capacitative calcium ion entry into the cell. Screening methods are also disclosed based upon using mammalian trp protein as a screening target.
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