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NON-LETHAL CONDITIONING METHODS FOR THE TREATMENT OF ACQUIRED IMMUNODEFICIENCY SYNDROME
NON-LETHAL CONDITIONING METHODS FOR THE TREATMENT OF ACQUIRED IMMUNODEFICIENCY SYNDROME
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机译:用于治疗获得性免疫缺陷综合症的非致命性方法
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摘要
The present invention relates to the use of a non-lethal preparative regimen for the treatment of a patient with human immunodeficiency virus (HIV) disease. In a clinical trial, an HIV-positive patient was conditioned by non-lethal doses of irradiation and a chemotherapeutic drug prior to receiving donor bone marrow cells from a baboon. While long-term engraftment of donor cells was not observed, the non-lethal preparative conditioning regimen was able to reduce the viral burden and improve the clinical outcome. Such method is useful for treatment of patients with advanced acquired immunodeficiency syndrome (AIDS).
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