PRODUCTION OF HETERODIMER PDGF-AB BY MEANS OF A BICISTRONIC VECTOR SYSTEM IN MAMMALIAN CELLS

摘要

PCT No. PCT/EP93/02295 Sec. 371 Date Apr. 24, 1995 Sec. 102(e) Date Apr. 24, 1995 PCT Filed Aug. 26, 1993 PCT Pub. No. WO94/05786 PCT Pub. Date Mar. 17, 1994The recombinant production of PDGF-AB in mammalian cells is disclosed by means of a bicistronic vector system in which an IRES sequence is located between the first and second cistrons and in which the B chain coding gene is located in the first cistron. The disclosed expression unit allows the equimolor expression of the A and B polypeptide chains.