Block copolymers of poly (2-alkyl-2-oxazoline) with lactone ring compounds and their preparation

摘要

The present invention relates to a process for producing a poly (2-alkyl-2-oxazoline) represented by the general formula (I) in which a hydroxyl group is present at the terminal with a 2-alkyl-2-oxazoline monomer as a starting material, (2-alkyl-2-oxazoline) represented by the general formula (II) and a lactone ring compound by copolymerizing with a lactone ring compound such as a poly And a manufacturing method thereof.;The block polymer of the present invention is a useful polymeric material which is used as a drug-controlled release material which can regulate the drug inserted into the body of a human body, an animal, etc. to be continuously controlled and released at a constant time.;In the general formula (I), R represents methyl, ethyl or propyl, and n is an integer of 10 to 100.;In the general formula (II), R represents methyl, ethyl or propyl. n is an integer of 10 to 1001, m is an integer of 10 to 200, and an average molecular weight is in the range of 1,000 to 50,000.