Preparation of a novel Amphiphilic diblock copolymers of Poly-N-vinylpyrrolidone and Poly (D, L-lactide) by Ring Opening Polymerization(Abstract)

摘要

Polylactide, with good biocompatibility, high mechanical strength, and excellent shaping and molding properties has been extensively used in many fields. However, polylactide has poor hydrophilicity when it is used for the controlled delivery of protein and peptide drugs. One of the possible and promising approaches to overcome this problem is to introduce hydrophilic units into the aliphatic polyester. In this paper, a novel amphiphilic diblock copolymer was synthesized by bulk ring-opening polymerization with the stannous octoate as catalyst, D, L-lactide and hydroxy-terminated poly-N-vinylpyrrolidone (PVP-OH) as monomer. The result copolymers were characterized by IR, ~1H-NMR and GPC, and determined by contact angle and water uptake. The diblock copolymers showed higher water uptake, lower contact angle and better hydrophilicity. This phenomenon elucidated that copolymer should be a more powerful candidate for biomaterials when it was used in drug delivery system and tissue engineering in comparison with pure PDLLA.