BICYCLIC NITROGEN-CONTAINING DERIVATIVES OR THEIR SALTS WITH MINERAL AND ORGANIC ACIDS OR BASES, METHODS OF THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS

摘要

FIELD: organic synthesis. SUBSTANCE: invention relates to high-efficiency angiotensin II receptor antagonists and provides compounds with general formula I: where R_2B and R_3B, the same or different, are hydrogen, lower alkyl, lower fluoroalkyl, and lower thioalkyl; A_1B, A_2B, A_3B and A_4B are carbon or nitrogen, one or two of them being nitrogen and at least one of them being methyne group; R₃ is hydrogen, hydroxyl, alkyl, hydroxyalkyl, phenyl, alkoxycarbonyl, and thioalkyl; R₄ hydrogen, hydroxyl, arylalkyl, arylalkoxy, aryloxy, and arylamino groups. Compound I is prepared by reaction of compound II (formula ) with compound where are the same as R_2B and R_3B in compound I, are R₄ in which reactive groups can be protected, and alk is C₁-C₆-alkyl, to form compound III (formula ) that is further subjected to cyclization. Reaction is carried out in organic solvent. EFFECT: new efficient drugs prepared. 7 cl, 38 ex