where R - alkyl, alkenyl, R1B, R2B, R3B, R4B and R5B - hydrogen; R2B and R5B - hydrogen; R1B and R3B - one hydrogen and another - CO2R7 and -R1; R7 - hydrogen, alkyl or alkenyl; R1 - hydrogen, hydroxyl, alkylated carboxyl, radical - where Ra and Rb - hydrogen, alkyl or alkenyl. Method of synthesis of (I) involves interaction of (II) with (III) obtaining (IV) followed by removal of protecting groups. Pharmaceutical composition showing antagonistic action with regard to angiotensin II containing (I) as an active agent at effective amount. Synthesized compounds were used as drugs. ???EFFECT: improved method of synthesis. 4 cl, 1 tbl"/>
DERIVATIVES OF BENZIMIDAZOLE OR THEIR ADDITIVE SALTS WITH ORGANIC OR MINERAL ACIDS, OR WITH MINERAL OR ORGANIC BASES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF
首页>
外国专利>
DERIVATIVES OF BENZIMIDAZOLE OR THEIR ADDITIVE SALTS WITH ORGANIC OR MINERAL ACIDS, OR WITH MINERAL OR ORGANIC BASES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF
DERIVATIVES OF BENZIMIDAZOLE OR THEIR ADDITIVE SALTS WITH ORGANIC OR MINERAL ACIDS, OR WITH MINERAL OR ORGANIC BASES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF
展开▼
机译：苯并咪唑或其与有机或矿物酸或矿物或有机碱形成的添加剂盐的衍生物，其合成方法和基于其的药物成分
展开▼
页面导航
摘要
著录项
相似文献
摘要
FIELD: organic chemistry. SUBSTANCE: product: derivatives of benzimidazole (I) where R - alkyl, alkenyl, R1B, R2B, R3B, R4B and R5B - hydrogen; R2B and R5B - hydrogen; R1B and R3B - one hydrogen and another - CO2R7 and -R1; R7 - hydrogen, alkyl or alkenyl; R1 - hydrogen, hydroxyl, alkylated carboxyl, radical - where Ra and Rb - hydrogen, alkyl or alkenyl. Method of synthesis of (I) involves interaction of (II) with (III) obtaining (IV) followed by removal of protecting groups. Pharmaceutical composition showing antagonistic action with regard to angiotensin II containing (I) as an active agent at effective amount. Synthesized compounds were used as drugs. ???EFFECT: improved method of synthesis. 4 cl, 1 tbl
展开▼
机译：领域：有机化学。物质：产品：苯并咪唑的衍生物（I）<图像文件=“ 00000002.GIF” he =“ 49” id =“ imag0.2” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 47” />其中R -烷基，烯基，R 1 B，R 2 B，R 3 B，R 4 B和R 5 B-氢; R 2 B和R 5 B-氢; R 1 B和R 3 B-一个氢和另一个-CO 2 R 7 和-R 1 ; R 7 -氢，烷基或烯基; R 1 -氢，羟基，烷基化的羧基，自由基-<图像文件=“ 00000003.GIF” he =“ 14” id =“ imag0.3” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 8” />，其中Ra和Rb-氢，烷基或烯基。 （I）的合成方法涉及（II ）<图像文件=“ 00000005.GIF” he =“ 26” id =“ imag0.5” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 47” />（III）<图像文件=“ 00000006。 GIF“ he =” 26“ id =” imag0.6“ imgContent =” undefined“ imgFormat =” GIF“ wi =” 37“ />获得（IV）<图像文件=” 00000007.GIF“ he =” 53“ id =“ imag0.7” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 53” />，然后删除保护组。对含有（I）的血管紧张素II表现出拮抗作用的药物组合物<图像文件=“ 00000008.GIF” he =“ 49” id =“ imag0.8” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 47” />作为有效量的活性剂。合成的化合物用作药物。效果：改进的合成方法。 4厘升，1汤匙
展开▼
