(S)Pmp¹, D-Trp², Pen⁶, Arg⁸--OXYTOCIN

摘要

FIELD: medicine, hormones. SUBSTANCE: invention relates to oxytocin antagonist of the formula (I) where (S)Pmp is , --(3-thiapentamethylene)----mercaptopropionic acid; D-Trp is D-form of tryptophan and Ile, Gln, Asn, Pro; Arg is L-form of isoleucine, glutamine, asparagine, proline and arginine, respectively, and Pen is penicillamine residue. This compound can be administrated to pregnant women to delay immature delivery and avoid unwanted adverse effects because of antagonism of human antidiuretic hormone vasopressin. EFFECT: enhanced effectiveness of oxytocin antagonist. 2 cl, 4 tbl, 11 ex