Recovery of hyaluronic acid from fermentation solution comprises reacting with chitosan salt and treating with aqueous alkali

摘要

Recovery of hyaluronic acid by precipitation from a polyelectrolyte complex comprises reacting a hyaluronic acid-containing fermentation solution or brew with at least one equivalent of a chitosan salt solution. The resulting hyaluronic acid-chitosan complex is separated out and treated with aqueous alkali, the insoluble chitosan is separated off and the hyaluronic acid alkali salt is precipitated out from the alkaline or neutral solution before being washed and dried.