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Genomic dna - fragments of streptococcus pneumoniae, hybrida tion probes, amplification primers and method for the detection of
Genomic dna - fragments of streptococcus pneumoniae, hybrida tion probes, amplification primers and method for the detection of
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机译:基因组dna-肺炎链球菌片段,杂交探针,扩增引物和检测方法
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摘要
The invention relates to a fragment of the genomic DNA of Streptococcus pneumoniae, to a probe capable of specifically hybridising with the genomic DNA of Streptococcus pneumoniae, to a specific primer for amplification of the said genomic DNA by polymerization, to a reagent and a process, used with the said probe and optionally with the said primer, for selectively detecting the Streptococcus pneumoniae in a biological sample. The probe of the invention comprises a nucleotide sequence having at least 70 % homology with at least a portion of a consensus sequence of the genomic DNA of Streptococcus pneumoniae, this consensus sequence being chosen from the nucleotide sequences SEQ ID NO 2, SEQ ID NO 3, SEQ ID NO 4, which are identified in the description, and their respective complementary sequences.
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机译:本发明涉及肺炎链球菌的基因组DNA的片段,能够与肺炎链球菌的基因组DNA特异性杂交的探针,用于通过聚合扩增所述基因组DNA的特异性引物,试剂和方法,与所述探针以及任选地与所述引物一起使用,用于选择性地检测生物样品中的肺炎链球菌。本发明的探针包含与肺炎链球菌基因组DNA的共有序列的至少一部分具有至少70%同源性的核苷酸序列,该共有序列选自核苷酸序列SEQ ID NO 2,SEQ ID NO 3。说明书中标识的SEQ ID NO:4及其各自的互补序列。
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