Process for the stereoselective preparation of a - phenylisoserine derivative and its use for the preparation of taxane derivatives

摘要

This invention relates to a method of stereoselective preparation of a derivative of -phenylisoserine of formula (I) by the action of an N- carbonyl-benzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formula (I), (II) or (III), R is an optionally substituted phenyl radical or R.sub.1 --O, Ar is an optionally substituted aryl radical and G.sub.1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties. ##STR1##