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Creation of human apolipoprotein E isoform specific transgenic mice in apolipoprotein deficient 'knockout' mice
Creation of human apolipoprotein E isoform specific transgenic mice in apolipoprotein deficient 'knockout' mice
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机译:在载脂蛋白缺乏的“敲除”小鼠中创建人载脂蛋白E同工型特异性转基因小鼠
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摘要
A transgenic mouse that expresses the human Apo E isoforms Apo E2, Apo E3 or Apo E4 but is essentially incapable of expressing endogenous Apo E. Additionally, mice that express more than one of these isoforms are produced by selectively breeding the transgenic mice expressing the different Apo E isoforms disclosed herein. Thus, the present invention allows, among other things, the study of the effects of different combinations of human Apo E isoform expression on normal brain biology, development, function, aging and injury.
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