TRANSGENIC 'KNOCK OUT' MICE EXPRESSING A HUMAN APOLIPOPROTEIN E

摘要

A transgenic nonhuman animal that expresses the human Apo E isoform Apo E2,Apo E3 or Apo E4 but is essentially incapable of expressing endogenous Apo E.Additionally, animals that express more than one of these isoforms areproduced by selectively breeding the transgenic animals expressing thedifferent Apo E isoforms disclosed herein. Thus, the present invention allows,among other things, the study of the effects of different combinations ofhuman Apo E isoform expression on normal brain biology, development, function,ageing and injury.