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Competitive assays using chemiluminescent electron-rich aryl- substituted 1,2-dioxetanes
Competitive assays using chemiluminescent electron-rich aryl- substituted 1,2-dioxetanes
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机译:使用富化学发光电子的芳基取代的1,2-二氧杂环丁烷进行竞争性分析
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摘要
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting pattern of the molecule results in a very high luminescent count, thus providing for a sensitive and precise assay for haptens, analytes, polynucleotides and the like. These substituted aryl-containing 1,2-dioxetane compounds can be used as direct labels in an immunoassay or when derivatized with an appropriate leaving group, can be used as a substrate for a enzyme immunoassay. The unusual chemiluminescence of the compounds allows the timing of the luminescent reaction to be exactly controlled.
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